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They are also supported by the finding that long-term administration of recombinant IGF-1 in humans with GH receptor deficiency is associated with decreased fat mass, increased lipolysis, and a faster rate of lipid oxidation (116)
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Furthermore, hyperglycemia and elevated free FAs associated with diabetes altered the palmitoylation state and activity of APT1, resulting in disrupted endothelial cell membrane dynamics and vessel integrity [81]
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