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Furthermore, resveratrol protects against acetaminophen-induced liver toxicity by upregulating Sirtuin 1 (SIRT1) expression, inhibiting p53 signaling, stimulating hepatic cell proliferation, and enhancing liver regeneration through the elevation of cyclin D1 and Cyclin-Dependent Kinase 4 (Cdk4) levels [60]
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4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells
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