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Chronic inflammation, driven by immune cell infiltration (macrophages, T cells, B cells) and pro-inflammatory cytokines (IL-1ฮฒ, TNF-ฮฑ, IL-6), activates signaling pathways such as NF-ฮบB and MAPK, promoting disc cell apoptosis and extracellular matrix (ECM) degradation (Figure 1)
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Blumenfeld AM, Varon SF, Wilcox TK, et al
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