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124 The British Society of Haematology published its guidelines on vitamin B12 and folate screening in 2014, at which time they stated that “no definitive advice can be given on the desirable frequency of monitoring” of vitamin B12 in those with T2DM having metformin therapy but recommended that serum B12 be measured “in the presence of strong clinical suspicion of deficiency”, 149 which we would opine may be difficult since deficiency is often asymptomatic

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