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However, cotreatment with halofuginone strengths the effects of conventional anticancer drugs in a xenograft tumor model, such as cisplatin or doxorubicin, illustrating a novel therapeutic cotreatment that alleviates Nrf2‐mediated chemoresistance.161 Metformin, a drug widely used in the treatment of type 2 diabetes, reduces mRNA and protein levels of Nrf2 through the suppression of Raf/ERK/Nrf2 signaling.162 Another postulated mechanism is that metformin may induce miR‐34a that decreases the protein expression of Nrf2 through the Sirt1/PGC‐1α/Nrf2 signaling.163 Conversely, metformin represses cancer cell growth and induces autophagy through the AMPK/mTOR pathway, which could also potentially activates Nrf2 in a p62‐dependent manner.164 Another therapeutic drug for type II diabetes, trigonelline inhibits Nrf2‐dependent proteasomal activity and interferes with Nrf2 nuclear import at low concentrations (0.0001‐1 μmol/L).165 The research of metformin and trigonelline in combination therapy with cancer chemotherapeutic drugs is currently ongoing