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The maturation of selenocysteine-tRNA can be regulated by the pentadienoic acid (MVA) pathway, which in turn can impact the synthesis of GPX4 and the development of ferroptosis (52)
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We also calculated the HOMA-IR index (homeostatic model assessment of β -cell function and insulin resistance) using the formula HOMA − IR index = fasting insulin (U/ml) × fasting glucose (mM)/22.5 [55]
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