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However, DNA hypermethylation status in sputum has been detected in LC patients in recent years ( SHOX2 and RASSF1A in bronchoalveolar lavage fluid has been shown to perform methylation analysis, with higher sensitivity and specificity compared to conventional cytology and serum CEA in the diagnosis of LC (Zhang et al., 2017)

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10.1016/j.cmet.2014.07.024 213 MuendleinH