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( h ) RT-qPCR analysis of selected neuronal marker genes in human E3*WT and E3*KO iNs (day 8 of culture)
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Many mechanisms have been proposed to explain MDR, such as the decrease in intracellular drug concentrations due to efflux pump induction, the mutation of drug targets, the upregulated metabolic detoxification, and the enhanced DNA damage repair function [63]
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