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Among the included studies, 6 studies reported local adverse reactions to acupuncture (discomfort, pain, bruising, hematoma), 5 studiesmentioned systemic adverse reactions (dizziness, nausea, weakness, vasovagal symptoms), while the remaining studies did not report any adverse reactions

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This is a small-molecule central nervous system reuptake inhibitor acting on three neurotransmitters, so investigators use it in satiety and monoamine signaling models