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Histones H3 and H4 undergo the majority of these modifications, although histones H2A and H2B also are subject to some alterations
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That seems to be the major source of the MDMA effect, so to speak, based on the work of our colleague, Rob Malenka, and at least one human study comparing MDMA to very high dose oxytocin treatment kind of ruled out the oxytocin spike that's induced by MDMA as the source or the only source, but of course, these chemicals can synergize
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