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Notably, although classic urea cycle enzymes such as CPS1 and OTC are generally downregulated in activated HSCs, atypical modular reassembly occurs within the cell: under the co-regulation of NO and TGF-β, the affinity of the HNF-3β binding site in the CPS1 promoter increases, allowing CPS1 to be maintained at low to moderate expression, continuously generating carbamoyl phosphate and NAG and supplying essential intermediates for ARG2-driven ornithine production and the polyamine pathway (31,112-115)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Firestein G