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Doctor Explains How DSIP Peptide Improves Sleep, Lowers Stress & More (DSIP Explained)

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The bZip in Neh1 domain allows Nrf2 to heterodimerize with small musculoaponeurotic fibrosarcoma proteins (sMafs).1 The Neh2 domain allows Nrf2 to bind and regulate its cytoplasmic chaperone molecule Kelch‐like‐ECH‐associated protein 1 (Keap1) in physiological manner.2 The two motifs of Neh2 domain, ETGE and DLG, bind to similar sites on the bottom surface of the Keap1 Kelch motif.3 Neh3 domain is necessary for protein stability and transcriptional activation.4 Neh4 and Neh5 function as two transactivation domains by interacting with CREB‐binding protein (CBP).2 Neh6 domain is rich in serine residues and contains a degron that is involved in the degradation of Nrf2 in oxidatively stressed cells.5 The activity of this degron could be increased by glycogen synthase kinase‐3 (GSK‐3) activity, suggesting that the stimulation of the degron of Neh6 domain could be an effective method to overcome the constitutive upregulation of Nrf2.6 2