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840 Hemato – Oncology Osler-Weber-Rendu, an Early Presentation Cristina Rodrigues 1 , Joana Vilaça 1 , Ana Ribeiro 1 , Joana Macedo 1 , Helena Silva 1 , Almerinda Pereira 1 1 Department of Pediatrics, Hospital de Braga, Portugal Background: Osler-Weber-Rendu syndrome is a rare autosomal dominant disease characterized by telangiectasias and arteriovenous malformations, which may affect multiple organs
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Either AGE, HMGB1, S100, or mtDNA induce AIM2 or NLRP3 inflammasome activation which plays a critical role in the pathogenesis of type 2 diabetes [164, 165]
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