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4.2 Level a studies: causal chain closed-loop evidence (ABX → FMT → rescue/in vivo blocking) 4.2.1 Er miao san (EMS) ABX (Microbiota Dependence/Necessity Signal): The study utilized an antibiotic cocktail (ABX) to deplete or significantly perturb the gut microbiota of recipient mice, testing whether EMS efficacy relies on microbial presence (Xu et al., 2025)
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Food Intake Suppression: Reduces meal size and frequency via CNS-mediated anorectic pathways [Nauck 2021]
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