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ER stress might promote NASH by aggravating diet-induced steatosis (Lee et al., 2008, Oyadomari et al., 2008, Rutkowski et al., 2008), and ER stress has also been shown to directly activate inflammatory signaling cascades (Lebeaupin et al., 2018, Özcan et al., 2004, Willy et al., 2015) and to promote hepatocyte cell death (Iracheta-Vellve et al., 2016, Olivares and Henkel, 2015)

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