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This review also highlights the beneficial effects of SOD mimetics and thus may probably be the future of OS targeted therapies in neurological disorders

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This was well demonstrated in a secondary analysis of the EPANIC study, in which 757 patients participated and which showed that a reduction in production of sCr positively correlated with the length of stay in the ICU, probably due to loss of muscle mass.15 The other parameter of AKI is oliguria, which is neither sensitive nor specific, since it could occur as a result of a kidney injury, but may also reflect an adaptive physiological response to either intracellular dehydration or hypovolemia.16 Only a small proportion of oliguric patients in the ICU have in fact a sustained fall in GFR which is reflected in an increase in sCr.16 Similarly, Mandelbaum et al.17 showed that only pronounced ( 12h) episodes of oliguria were associated with the need to start renal replacement therapy (RRT) or with increased hospital mortality