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Cell Death Dis 2017;8:e2903 [DOI] [PMC free article] [PubMed] [Google Scholar] 34.Hanawa N, Shinohara M, Saberi B, Gaarde WA, Han D, Kaplowitz N.Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury
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Then, L-theanine alone or in combination with theobromine could effectively inhibit tumor production in male Wistar rats with colon cancer induced by dimethylhydrazine, and the mechanism of action was related to downregulating the Akt/mTOR (mammalian target of rapamycin) and JAK2/STAT3 pathways and increasing the mRNA and protein expression of tumor suppressor Smad2 (73)
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