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Neurotrophin Signaling Cascade : Upon TrkB binding, the compound activates downstream signaling pathways including PI3K/Akt and MAPK/ERK cascades, which promote neuronal function and support synaptic strength in brain regions that support memory formation
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In agreement with this, we observed the highest expression of PrP in cholangiocarcinoma nodes in the liver of Atp7b −/− mice, whereas PrP depletion almost completely prevented tumor growth
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