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Functional cooperation between the B-cell receptor and NOTCH1 in regulating metabolic reprogramming in chronic lymphocytic leukemia | Leukemia

A.CorreaM.ArizziM

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The enzymatic activity of specific respiratory chain complex subunits and mitochondrial biogenesis was shown to be stimulated by short-term exposure to stress-level GCs, while extended GC exposure led to mitochondrial structural alterations, respiratory chain dysfunction, excessive ROS production, apoptosis, and eventual cell death [163,164]