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Progesterone withdrawal through ROS-induction stimulates the activity of NF-κB/COX2 signaling as well as cytokines (IL1, IL6, IL8, TNF-α, etc.) and matrix metalloproteinases (MMPs) activation [23] resulting in an influx of leukocytes into the uterus and leading into the endometrial breakdown and shedding [16]
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