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Interestingly, products of this cleavage often act proapoptotic in a positive feedback loop ( Therefore, the mitophagy pathway can be regulated by modulating the level of endogenous molecular substances, such as nicotinamide (NAM) and other silent information regulator T1 (SIRT1) activators, p62/SQSTM1-mediated mitophagy reducer (PMI), GSK-3Ξ², PTEN/L, apurinic/apyrimidinic endonuclease 1
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