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Given the established direct interaction between GCN5 and TADA2B, we investigated whether either protein might indirectly bind to XRCC1 through the other
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[109] The advanced lead compound 87 exhibited good biochemical and cellular potency (PI3δ pIC 50 = 7.7 and PI3δ hWB pIC 50 = 7.6) but with moderate clearance (Cl = 41 mL/min/kg)
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