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The Wnt (Wingless/Integrated) signaling pathway takes part in a variety of pathological symptoms such as maintenance, differentiation, proliferation, and self-renewal in RA
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Histone acetylation is associated with transcriptional activation and is thus an activation mark, as acetylation neutralizes the positive charge of lysine residues and causes the weakening of DNA and histone interactions leading to “looser” chromatin
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