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106 Following pioneering studies that linked CBS overexpression with colorectal and ovarian cancer (Table 1), an increase in the expression of all enzymes involved—individually or jointly—in the synthesis of H 2 S has also been reported for breast, gastric, lung, liver, bladder, kidney and prostate carcinomas, melanoma, neuroblastoma, glioma and astrocytoma

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In addition, in Acipenser sturgeon ( Acipenser transmontanus ), excessive Se in the diet leads to vacuolar degeneration of cells and necrosis of the liver (Tashjian et al., 2006)