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Elevated intracellular iron levels facilitate the generation of ROS through Fenton chemistry, subsequently initiating lipid peroxidation reactions ( Compared with other forms of cell death such as apoptosis, necrosis, and autophagy, ferroptosis exhibits distinct molecular mechanisms and biological features ( Table 1 ): (1) Iron Dependence: Ferroptosis is uniquely triggered by elevated intracellular iron levels, differentiating it from other cell death modes