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Most of their ingredients are well-tolerated in the hundreds of studies we’ve reviewed, but there are some exceptions worth noting: Nitric oxide boosters (citrulline, arginine, etc.) This class of ingredients may present the most significant danger to men and women with heart conditions, as increasing nitric oxide can cause an unsafe drop in blood pressure, especially if you’re already taking medications to lower it.15 Ashwagandha Mass gainers and protein powders Mass gainers and meal replacements often have high caloric loads, which can lead to weight gain — both fat and muscle

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