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It plays a pivotal role in glucose metabolism and appetite regulation through multiple mechanisms: Enhances insulin secretion: GLP-1 stimulates pancreatic β-cells to release insulin in a glucose-dependent manner Suppresses glucagon: Reduces hepatic glucose production Delays gastric emptying: Creates prolonged satiety Central nervous system effects: Acts on appetite centers in the brain to reduce hunger and food intake Protects pancreatic β-cells: Promotes cell proliferation and inhibits apoptosis GLP-1 Receptor Agonists in Clinical Practice GLP-1 receptor agonists (GLP-1 RAs) are medications designed to mimic the action of endogenous GLP-1 but with enhanced pharmacokinetic properties

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Membranes were blocked (Blocking Buffer, Odyssey ® , Li-Cor, Lincoln, NE, USA) and target proteins were probed with the following primary antibodies: β-actin (Sigma SAB1305546) 1:10,000 dilution, NAD(P)H dehydrogenase [quinone] 1 (NQO1) (Abcam Cat# ab2346, RRID:AB_302995) 1:500 dilution, nuclear factor (erythroid-derived 2)-like 2 (Nrf2) (R&D SYSTEM MAB3925) 1:500 dilution