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In vivo studies confirmed that Ghrelin significantly activated the BMP6/SMAD1 signaling pathway in the brain tissue of AD mice, thereby inhibiting microglial ferroptosis, promoting microglial polarization toward the M2 phenotype, and ameliorating learning and memory deficits in AD mice (Guo et al., 2025b)
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By scavenging ROS, the human body can lower the risk of developing these conditions, thereby enhancing overall quality of life (Gülçin 2012
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