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4.2 Focus and frontiers Two previous bibliometric studies on PSCI visualized relevant data using bibliometric software (Chi et al., 4.2.1 Risk factors for PSCI Several risk factors are associated with PSCI (Desmond et al., A history of cerebral infarction is a key predictor of PSCI (Shim, 4.2.2 Pathogenesis of PSCI The specific mechanisms underlying PSCI remain unclear and involve several factors, including cerebrovascular injury, neurodegenerative processes, genetic influences, inflammation, and molecular changes (Li et al., The molecular mechanisms mainly include damage to the cholinergic transmission pathway, excitotoxicity, and oxidative stress (Zuo et al., Currently, “functional connectivity” are research hotspots, attracting widespread attention from scholars