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The accumulation of autolysosomes in the brain from AD patients mirrors the condition of compromised lysosomal proteolysis obtained via genetic knockdown of specific cathepsins or use of pharmacological inhibition of lysosomes (364–366)
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Folic Acid, vitamin B9 is not a substitute for methylcobalamin, vitamin B12 deficiency, although it may improve vitamin B12 megaloblastic anemia
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