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This metabolic shift subsequently modulates the expression of CXCL14 (C-X-C Motif Chemokine Ligand 14), a protein implicated in the regulation of macrophage homeostasis, contributing to the polarization of M0-type tumor-associated macrophages (TAMs) towards the M2 phenotype, which is associated with enhanced motility and proliferative capacity of NB cells [157]

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The drawbacks of conventional chemotherapy, such as severe toxicity, lack of specificity related to actively dividing cells, and resistance, can warrant the urgent need to develop an alternative approach to treat this disease