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b , Total GPX4 enzymatic activity (endogenous apo-GPX4 and transfected exogenous GFP-tagged-GPX4) of control HT1080 (pBP, no expression of GFP-tagged-GPX4) and HT1080 cells overexpressing GFP-GPX4 WT or GFP-GPX4 R152H
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Oxidative DNA damage results in mutations that generate dysfunctional protein gene products and altered replication and transcription of crucial genes (44, 53–55)
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