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Older adults (60+) – May benefit from extended escalation intervals (6 weeks per step instead of 4) due to: Slower metabolic adaptation Increased medication sensitivity Higher likelihood of comorbid conditions Potential polypharmacy interactions Body Weight and Composition Factors Unlike some medications dosed per kilogram of body weight, cagrilintide uses fixed dosing regardless of baseline weight

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15 Nonetheless, many patients have been taking these medications for years and are reluctant to discontinue them