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Biodistribution experiments in mice bearing HER2-positive NIH3T6.7 xenografts found that the administration of azide-bearing variants of maltose and glucose 1, 3, and 5 h after the injection of [ 111 I]I-trastuzumab significantly reduced residual radioactivity levels in the blood without substantially affecting uptake in other healthy tissues (Figure )

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This single assay yields a wide range of parameters, providing insight into mitochondrial dysfunction and reveals the functional differences between cell types, cellular metabolic state (quiescent versus active), effect of drug candidates, impact of genetic modifications, or biochemical interactions [146]