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These changes included consistent increases (transketolase, mitochondrial creatine kinase) and consistent decreases (proteasome subunits alpha type 3, alpha type 6, 26S non-ATPase 14), as well as biphasic patterns in which proteins increased in expression through adulthood but decreased with aging (amphiphysin, dynamin, voltage-dependent anion channel 1)

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Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions