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Among these, the expression of 16 was upregulated, whereas that of 6 was downregulated, including manganese superoxide dismutase (Mn-SOD), the p85 subunit of PI3K, and proteasome activator complex subunit 3 (PA28-α)

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Risk-based treatment assignment is used in children with ALL so that patients with favorable clinical and biological features who are likely to have a very good outcome with modest therapy can be spared more intensive and toxic treatment, while a more aggressive, potentially more toxic therapeutic approach is reserved for patients with a lower probability of long-term survival.[1,2] Certain ALL study groups, such as the Children’s Oncology Group (COG), use a more- or less-intensive induction regimen based on a subset of pretreatment factors, while other groups give a similar induction regimen to all patients