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Future studies should therefore combine genetic perturbation, selective pharmacological tools, rescue experiments, temporal metabolic profiling, patient‐derived organoids, immunocompetent models, and longitudinal clinical specimens
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Research demonstrates that TB-500 administration mobilizes EPCs from bone marrow reservoirs, with animal studies showing 3-fold increases in circulating EPC numbers that contribute to neovascularization through both structural incorporation into developing vessels and paracrine secretion of pro-angiogenic factors
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