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“This study identifies aspartate as one such limiting metabolite, and suggests that its availability could be targeted for anti-cancer therapies.” Birsoy is a former postdoc in professor of biology David Sabatini’s lab, who authored a paper published in the same issue of Nature Cell Biology , identifying aspartate as a major growth limitation in oxygen-deprived tumors

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The antioxidant properties of vitamin B12 are discussed to be accomplished by different mechanisms, including direct scavenging of ROS, particularly superoxide in the cytosol and mitochondria [108,109] and indirectly stimulating ROS scavenging by preservation of glutathione [110,111]