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Background of ferroptosis The term ‘ferroptosis’, which was coined in 2012, characterizes an abnormal form of RCD that is distinguishable from apoptosis, autophagy, as well as pyroptosis by exhibiting smaller mitochondria, disappearing mitochondrial crest, and increased mitochondrial membrane density but not chromatin condensation and margination, cytoplasmic and organelle expansion, plasma membrane rupture, or double-membrane contained vesicles [8]

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Also, we emphasized[1] that Robert’s concept[14-17] largely applied the antecedent Selye’s stress concept[88,89] which essentially contributed[90] to the introduction of corticosteroid therapy[91]