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As discussed in another review on the same issue of this journal, oxidative stress also plays a role in GO, and the beneficial effect of antioxidant agents are supported by in vitro and human studies (1–6, 11, 37–46)

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Nelson DB, Niu J, Mitchell KG, Sepesi B, Vaporciyan AA, Hofstetter WL, Walsh GL, Swisher SG, Roth JA, Antonoff MB, Mehran RJ, Rice DC