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Although direct evidence in native sepsis models is currently lacking, mechanistic insights from viral infection (such as influenza A virus) models demonstrate that IRF1 directly binds to the FSP1 promoter as a transcriptional repressor, downregulating FSP1 expression and facilitating ferroptosis (75)

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Instead, if FDA adopts the recommendations, eligible 503A pharmacies could compound patient-specific medications using the peptides pursuant to valid prescriptions, consistent with the requirements of the Federal Food, Drug, and Cosmetic Act (FD&C Act)