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Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1

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Interestingly, loss of its receptor SLC22A17 did not reverse this effect, suggesting that LCN2 modulates System Xc - -GPX4 pathway through mechanisms independent of SLC22A17