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However, a critical gap across these studies is the general lack of investigation into whether and how these autophagy-modulating agents affect ferroptosis, which limits the assessment of their full relevance to the core crosstalk theme

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It was also observed that GCN2 is activated in mice in response to treatment with asparaginase 99 , which is approved by the US Food and Drug Administration (FDA) for the treatment of acute lymphoblastic leukemia (ALL) and may deplete serum asparagine and glutamine 100–102