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The activated NF-κB: - by inducing cytokines (TNF-α, IL-6, MCP-1) that are pro-inflammatory, brings about inflammation in adipose tissue - through the disturbance of the insulin receptor signaling, reduced glucose uptake, and high blood glucose, causes resistance to insulin - through the reduction of fatty acid oxidation and the increase in the accumulation of lipids, it also does this in the liver, thus contributing to the overall metabolic dysregulation Flavonoids and phenolics among others found in nature are known to block NF-κB activation leading to a reduction of inflammation, enhancement of insulin sensitivity, decrease of liver fat accumulation, and protection against the development of metabolic disorders related to obesity

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