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To target HSCs, the primary drivers of fibrosis in MASLD/MASH, several studies have modified the surface receptors of HSCs or specific ligands of highly expressed receptors, such as mannose-6-phosphate/insulin-like growth factor II (M6P/IGF-II) [172], PDGF receptor [173], and retinol-binding protein receptor, on the surface of NPs to selectively deliver antifibrotic drugs to HSCs [174]
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