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Therefore, although this issue remains incompletely studied, we think that the body of information summarized in this review supports the concept that among the numerous situations where RBC rigidification has been reported to occur, some involve reversible changes in a fully physiological context, while others reflect quite irreversible damage to the red cells that will lead to eryptosis (Figure 4)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Tschopp J, Schroder K