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Everyone hears the word “peptides” and assumes they're all for weight loss. They're not. That's kind of like saying every medication is for the same thing. Different peps have different purposes. Some

Together with computational studies, our structure unveils the binding cavity inside the 7-TM bundle for NADPH and steroid substrates with flexible cytosolic loops

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Conversely, the reverse reaction for off-target effects may be thermodynamically favored, but if the kinetics of dissociation are slow, then the off-target effects may be significant since there may be a long-residence time of the inhibitor and the off-target enzyme, which leads to no functional difference between reversible inhibition and irreversible inhibition on the time scale of cellular stress response