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[DOI] [PubMed] [Google Scholar] Yuneva AO, Kramarenko GG, Vetreshchak TV, Gallant S, Boldyrev AA
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The binding of islet to IR can phosphorylate IR dimer tyrosine, which in turn phosphorylates insulin receptor substrate (IRS), activating downstream phosphatidylinositol 3-kinase, PI3K/protein kinase B and mitogen-activated protein kinase (MAPK) to produce downstream effects (Manning and Cantley, 2007
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