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According to Han et al., H19 could control the expression of cell-cycle regulatory genes including cyclin D1, cyclin E1, and Cyclin Dependent Kinase 4 (CDK4) by combining with the Eukaryotic Translation Initiation Factor 4A3 (eIF4A3) and hampering the recruitment of eIF4A3 to their transcripts, thus accelerating cell-cycle progression and CRC proliferation ( in vitro and tumor growth and metastases in vivo by sponging miR-138 thereby increasing the expression of HMGA1 ( It is well known that eukaryotic genomes are transcribed in both sense and antisense directions, producing abundant levels of noncoding RNAs (107)

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