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The absorption of oxalates is regulated in the intestines by being bound to calcium, limiting their absorption, so anything that disrupts calcium in the intestines can affect oxalate levels.[ref] Related article : Pancreatic Enzyme Insufficiency 3) Endogenous oxalate formation There are two main sources of oxalate created in the body as a metabolite.[ref] Vitamin C (ascorbic acid) is broken down into oxalate without needing enzymes

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The loss of glutathione activity extends to blood serum [10,11] and is also found in patients being treated with methadone and buprenorphine [12]